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© 1990 Oxford University Press

research-article

Silica Exposure and Lung Cancer in Ceramic Workers: A Case-Control Study

JAN M M MEIJERS*, GERARD M H SWAEN*, ALEX VOLOVICS**, JOS J M SLANGEN* and KEES VAN VLIET*

*Department of Occupational and Environmental Health and Toxicology PO Box 616, 6200 MD Maastricht, The Netherlands.
**Department of Biostatistics, University of Limburg PO Box 616, 6200 MD Maastricht, The Netherlands.

Meijers JMM (Department of Occupational and Environmental Health and Toxicology, University of Limburg, PO Box 616, 6200 MD Maastricht, The Netherlands), Swaen GMH, Volovics A, Slangen JJM and van Vliet K. Silica exposure and lung cancer in ceramic workers: A case-control study. International Journal of Epidemiology, 1990, 19: 19–25.

The results are presented from a case-control study, concerning the possible relation between silica exposure in the Dutch fine ceramic industry and lung cancer. For this purpose 381 male, age-matched pairs of primary lung cancer cases and controls were selected from the pathology department of the University Hospital in the region, where two large ceramic companies are located. Information about employment in the ceramic industry was obtained from the personnel and financial administration departments of the two companies. On the basis of job titles a panel of occupational hygiene experts reached consensus about the qualitative exposures of each individual worker. Twenty one percent of the cases were employed in the ceramic industry, compared with 19% of the controls (odds ratio 1.11, 95% Cl: 0.77–1.61). Although the average employment period of cases and their relative silica exposure surpassed those of controls, odds ratios for long duration of employment and considerable exposure to respirable silica dust did not reach statistical significance. After constructing a qualitative exposure index, based on the amount and duration of exposure, a tendency towards a positive correlation with lung cancer emerged. No relation between specific histological tumour cell types and working in the ceramic industry emerged. Although the study does not suggest a consistent cause-effect relation between silica exposure in the regional, Dutch fine ceramic industry and lung cancer, an increased risk for the high exposure group in the past can not be totally excluded.

Revised 1 June 1989


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