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© 1989 Oxford University Press

research-article

Alcohol Use and Retinal Vessels: Insights into the Mechanism of Alcohol-Induced Stroke

MICHAEL J KLAG, RICHARD D MOORE, YOSHIMICHI SAKAI*, SUMIO SASAKI, RICHARD W STONE* and GEORGE W COMSTOCK

Departments of Medicine, Epidemiology and Health Policy and Management, The John Hopkins Medical Institutions and the Medical Departments, American Telephone and Telegraph Company and Nippon Telegraph and Telephone Public Corporation
*These authors have sadly died since this paper was written

Klag M J (The Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, Maryland 21205, USA), Moore R D, Sakai Y, Sasaki S, Stone R W and Comstock G W. Alcohol use and retinal vessels: insights into the mechanism of alcohol-induced stroke. International Journal of Epidemiology 1989, 18: 619–625.

Alcohol use is a recognized risk factor for stroke. We hypothesized that alcohol use may increase the risk of stroke, independent of an effect on blood pressure, by causing cerebral vasoconstriction. To examine this, we used retinal vessels as a marker for cerebral vessels and analysed the cross-sectional associations between alcohol use and total retinal vessel width in 741 Japanese and 434 American white male telephone executives. Systolic and diastolic blood pressures were negatively associated with retinal vessel width in the Japanese (p<0.0001, 0.0001, respectively) but this association did not achieve statistical significance in the Americans {p<0.1, 0.3). Japanese drinkers had a larger mean retinal vessel width than Japanese abstainers, while American drinkers had a smaller retinal vessel width than abstainers. These associations between alcohol use and retinal vessel width were not significant within nationalities but the interaction between alcohol use and nationality was significant, independent of other stroke risk factors (p<0.04). Although these results do not support the initial hypothesis, they are consistent with known biological differences in alcohol metabolism between Japanese and American men and support different effects of alcohol use on retinal vessel calibre in these two nationalities.

Received 1 February 1989


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