© 1989 Oxford University Press
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Lead, IQ and Social Class

* Department of Neurology, Harvard Medical School, and the Department of Neurology and the Mental Retardation Research Center, Children's Hospital Boston, Massachusetts, USA.
Department of Biostatistics, Harvard School of Public Health, and the Mailman Research Center of McLean Hospital Belmont, Massachusetts, USA.
Bellinger D (Department of Neurology, Harvard Medical School, Boston, Massachusetts, MA 02115, USA), Leviton A and Waternaux C. Lead, IQ and social class. International Journal of Epidemiology 1989, 18: 180185.
Social class (SC) conveys information about a child's potential lead exposure (PB) as well as other, independent determinants of cognition (IQ). Thus, depending on the way in which SC is handled in statistical analyses, the PB-IQ association may be either overadjusted or underadjusted for SC. Two assumptions that underlie the inclusion of SC in correlation/regression analyses of the PB-IQ relationship are: 1) SC is an interval scale and 2) the PB-IQ relationship is homogeneous in all social strata. Simulation analyses are presented to illustrate the impact that different values of the bivariate correlations PB-SC, IQ-SC, and PB-IQ have on the estimate of the PB-IQ adjusted for SC. Alternative approaches to addressing these issues are discussed.
Revised 1 September 1988
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