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© 1989 Oxford University Press

research-article

Lead, IQ and Social Class

DAVID BELLINGER*, ALAN LEVITON* and CHRISTINE WATERNAUX{dagger}

* Department of Neurology, Harvard Medical School, and the Department of Neurology and the Mental Retardation Research Center, Children's Hospital Boston, Massachusetts, USA.
{dagger} Department of Biostatistics, Harvard School of Public Health, and the Mailman Research Center of McLean Hospital Belmont, Massachusetts, USA.

Bellinger D (Department of Neurology, Harvard Medical School, Boston, Massachusetts, MA 02115, USA), Leviton A and Waternaux C. Lead, IQ and social class. International Journal of Epidemiology 1989, 18: 180–185.

Social class (SC) conveys information about a child's potential lead exposure (PB) as well as other, independent determinants of cognition (IQ). Thus, depending on the way in which SC is handled in statistical analyses, the PB-IQ association may be either ‘overadjusted’ or ‘underadjusted’ for SC. Two assumptions that underlie the inclusion of SC in correlation/regression analyses of the PB-IQ relationship are: 1) SC is an interval scale and 2) the PB-IQ relationship is homogeneous in all social strata. Simulation analyses are presented to illustrate the impact that different values of the bivariate correlations PB-SC, IQ-SC, and PB-IQ have on the estimate of the PB-IQ adjusted for SC. Alternative approaches to addressing these issues are discussed.

Revised 1 September 1988


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S J Pocock, M Smith, and P Baghurst
Environmental lead and children's intelligence: a systematic review of the epidemiological evidence
BMJ, November 5, 1994; 309(6963): 1189 - 1197.
[Abstract] [Full Text]



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