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© 1988 Oxford University Press

research-article

Family History of Autoimmune Disorders and Cancer in Multiple Myeloma

MARTHA S LINET*,{dagger},{dagger}, JOSEPH K MCLAUGHLIN{dagger}, SIOBAN D HARLOW* and JOSEPH F FRAUMENI{dagger}

*Department of Epidemiology, The Johns Hopkins School of Hygiene and Public Health 615 North Wolfe St, Baltimore, Maryland 21205, USA

Present address and reprint requests: Dr Martha S. Linet Analytic Studies Section, Biostatistics Branch, Epidemiology and Bkntatistics Program, Division of Cancer Etiology, National Cancer Institute Landow Building Room 3C15, Bethesda, MD 20892, USA

To explore genetic mechanisms that might underlie the relation observed between multiple myeloma and rheumatoid arthritis, we examined the occurrence of autoimmune disorders in first-degree relatives of myeloma cases and controls. There was a significant excess of rheumatoid arthritis (OR=3.7; 95% Cl=1.0–13.1) among the relatives of cases compared with controls, as well as an increased occurrence of systemic lupus erythematosus and pernicious anaemia. An excess of certain cancers was also observed among family members, including leukaemia and cancers of the breast, endometrium, and oral cavity and pharynx, but none of the excesses were significant These findings deserve further evaluation in larger population-based studies

Revised 1 August 1987


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