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© 1988 Oxford University Press

research-article

Increased Risk of Cancer in Siblings of Alaskan Native Patients with Nasopharyngeal Carcinoma

BELINDA IRELAND*, ANNE P LANIER*, LISA KNUTSON*, SUSAN E CLIFT{dagger} and ANNETTE HARPSTER*

*Arctic Investigations Laboratory, Center for Infections Diseases Centers for Disease Control, 225 Eagle Street, Anchorage, Alaska 99501, USA
{dagger}Alaska Native Medical Center Alaska Area Native Health Service, Third and Oambell Streets, Anchorage, Alaska 99510, USA

Alaskan Natives (Eskimos, Indians, Aleuts) are at increased risk of developing nasopharyngeal cancer (NPC) and there is family clustering of NPC. This study reviewed the total cancer experience of relatives of NPC patients and found that siblings of Eskimo NPC patients had a nearly threefold risk. No cancer family syndrome was identified and the cancers diagnosed in the siblings were similar to those seen in the general Alaskan Eskimo population.

Revised 1 October 1987


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