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© 1988 Oxford University Press

research-article

Serum Vitamin E Level and Risk of Female Cancers

PAUL KNEKT

Research Institute for Social Security, PO Box 78, SF-00381, Helsinki, Finland. Departments of Biomedical Sciences and Public Health, University of Tampere Tampere, Finland and Finnish Cancer Registry, Helsinki, Finland

A sample of 15 093 women, aged 15–99 and initially free from cancer, participated in the Finnish Social Insurance Institution's Mobile Clinic Health Survey in 1968–71. A record linkage to the Cancer Registry revealed that during a mean follow-up of eight years cancer was diagnosed in 313 women. Serum alpha-tocopherol levels were measured from stored samples (at –20 C) of the cancer patients and of 678 controls, matched for municipality and age. An inverse relation was observed between alpha-tocopherol level and risk of cancer, even if the cancers In the first two years of follow-up were excluded. Women in the lowest quintile for alpha-tocopherol levels compared to those with higher values had a 1.6-fold (95% confidence interval: 1.1–2.5) risk of cancer as adjusted for possible confounding effects of several other factors. A low level of alpha-tocopherol in general strongly predicted epithelial cancers while it carried an only slightly elevated risk of cancers in reproductive organs exposed to oestrogens. The results suggest that a low vitamin E intake is a risk factor for cancer in many, but not all, organs. The expression of its protective effect may depend on the primary causes, which vary between different cancers.

Revised 1 July 1987


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