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© 1987 Oxford University Press

research-article

Delta Hepatitis Virus Infection in China

DAO-QIN WANG, HE-HE CHENG, G Y MINUK, LI-HUA LIU, C M ANAND, T C STOWE, HONG-XI WANG, DA-CHANG YING, YUN-REN TU and K A BUCHAN

Division of Viral Diseases Control, Provincial Health and Anti-Epidemic Centre Chengdu, Sichuan, China
Division of Anti-Epidemic, Provincial Health and Anti-Epidemic Centre Kunming, Yunnan, China
Department of Medicine, the University of Calgary Calgary, Alberta, T2N 4N1 Canada
South Branch of Provincial Laboratory of Public Health, The University of Alberta Calgary Alberta, T2P 2M7 Canada

Reprint request to: Dr C Y Minuk, University of Calgary, Health Sciences Centre, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1 Canada.

To assess the prevalence, epidemological features and prognostic implications of hepatitis D (Delta) in Sichuan Province, The People's Republic of China, 649 sera (515 from HBsAg positive patients and 134 from HBsAg negative subjects) were tested by radioimmunoassay (RIA) for antibody to the hepatitis D virus (anti-HD).

Forty-seven sera (7.2%) showed some degree of reactivity. Serial dilutions of these sera indicated that prozoning was not responsible for the equivocal results. Thirty-four of the 47 sera were submitted under code to a second laboratory for independent analysis. According to those results anti-HD antibodies were detected in four of these sera. The overall prevalence of anti-HD in the HBsAg positive patients therefore was 0.8% (4/515). On the basis of clinical, biochemical and histological data 427 HBsAg positive sera were further divided into acute Type B hepatitis, chronic Type B hepatitis, hearthy carrier state and hepatocellular carcinoma (HCC) subgroups. Two of 65 (3.1%) anti-HD positive sera belonged to the acute Type B hepatitis group; one of 104 (0.9%), the chronic Type B hepatitis group and one of 246 (0.4%), the healthy carrier group. No antibody was detected in sers from 12 HBsAg positive HCC patients.

All HBsAg negative patients were negative for anti-HD antibody. The results of this study indicate that despite a high prevalence of hepatitis B virus infection, positive serology for delta virus is uncommon in Sichuan Province, The People's Republic of China.

Received 1 May 1986


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