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© 1986 Oxford University Press

research-article

An International and Interregional Comparison of Haemostatic Variables in the Study of Ischaemic Heart Disease

T W MEADE*, Y STIRLING, S G THOMPSON, M V VICKERS, L WOOLF, A B AJDUKIEWICZ, G STEWART, J F DAVIDSON, I D WALKER, A S DOUGLAS, I M RICHARDSON, R D WEIR, A AROMAA, O IMPIVAARA, J MAATELA and J HLADOVEC

*MRC Epidemiology and Medical Care Unit Northwick Park Hoipiial, Wail'ord Road. Harrow, Middles, HAI 3UJ. UK.
LONDON
GAMBIA
GLASGOW
ABERDEEN
FINLAND
PRAGUE

Levels of haemostatic variables that may be involved in thrombogenesis have been compared in groups of men of similar mean age in communities at very low (Gambia), high (England and Czechoslovakia) or very high (Scotland and Finland) risk of ischaemic heart disease (IHD). There was a consistent gradient of higher factor VII levers with higher IHD risk and also suggestive gradients in the case of two other vitamin K dependent factors, factors II and X. Mean platelet counts were lower and mean fibrinolytic activity was greater in Gambian men than in European men. There was a suggestive though not entirely consistent association between mean fibrinogen levels and IHD risk in the groups from IHD-endemic countries. The results as a whole, and particularly those on factor VII, strengthen the case for the increasingly detailed epidemiological as well as laboratory investigation of the role of the haemostatic system in thrombogenesis and IHD.

Received 1 November 1985


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