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© 1986 Oxford University Press

research-article

Serum Cholesterol and Cancer — A Retrospective Case-Control Study

MARIA GERHARDSSON*,**, URBAN ROSENQVIST{dagger}, ANDERS AHLBOM* and LARS A CARLSON{ddagger}

*Department of Epidemiology, National Institute of Environmental Medicine Box 60208, S-01 Stockholm, Sweden
**Department of Social Medicine, Huddinge University Hospital S-141 86 Huddinge, Sweden
{dagger}The Stockholm County Council, Teaching Centre for Diabetes, Karolinska Hospital S-104 01 Stockholm, Sweden
{ddagger}King Gustaf V Research Institute and the Department of Internal Medicine. Karolinska Hospital, Karolinska Institute S-104 01 Stockholm, Sweden

The time relationship between low serum cholesterol and the subsequent development of malignant neoplasms was examined in a case-control study of 100 cases of cancer death and 393 controls. The serum cholesterol levels were followed by repeated blood analysis over a 16-year period. An association between low serum cholesterol and cancer death was found particularly for malignant neoplasms of the large intestine and rectum. This relationship diminished 7–16 years prior to death suggesting that the low serum cholesterol levels were an effect of the cancer in an early stage and not vice versa.

Revised 1 September 1985


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