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© 1984 Oxford University Press

research-article

A Multivariate Analysis of the Risk Indicators of Reduction Limb Defects

TIMO ARO, JAASON HAAPAKOSKI and OLLI P HEINONEN

Department of Pathology, University of Helsinki Haartmaninkatu 3, SF-00290 Helsinki 29, Finland.

T (Department of Pathology, University of Helsinki, Haartmaninkatu 3, SF-00290 Helsinki 29, Finland), Haapakoski J and Heinonen 0 P. International Journal of Epidemiology 1984, 13: 459–464.

In order to evaluate associations of various selected risk indicators with reduction limb defects, data on 453 cases of reduction limb defects and their time-area matched pair controls from the Finnish Registry of Congenital Malformations was studied. A multivariate analysis of the earlier reported associations was performed. This analysis showed that the following risk indicators were associated with the defects: high birth order, threatened abortion, low placental weight, low birth weight, previous malformations in the family, influenza during early pregnancy, other infectious diseases, and mother's alochol consumption during pregnancy.


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