Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (85)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by DEPUE, R. H
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by DEPUE, R. H
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1984 Oxford University Press

research-article

Maternal and Gestational Factors Affecting the Risk of Cryptorchidism and Inguinal Hernia

ROBERT H DEPUE

Division of Cancer Epidemiology, National Cancer Institute Bethesda, Maryland, 20205, USA

Case-control studies of cryptorchidism and inguinal hernia were undertaken on white males born within the cohort of the Collaborative Perinatal Project of the National Institute of Neurological and Communicative Disorders and Stroke. Significantly elevated risks of cryptorchidism were found for low birthweight, for a high maternal Quetelet's index and for oestrogens administered during gestation (R =2.8). Similarly, in the case of inguinal hernia, significantly increased risk ratios were observed for low birthweight, for gestational use of progestins (RR = 2.1), and for breech labour (RR = 2.3). Because these malformations and testis cancer share many of the same risk factors, a common mechanism for production of these diseases is proposed which is mediated by testicular hypoplasia induced by excess exogenous or endogenous oestrogen in the mother.

Received 1 January 1984


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am J EpidemiolHome page
T. H. Schnack, S. Zdravkovic, C. Myrup, T. Westergaard, J. Wohlfahrt, and M. Melbye
Familial Aggregation of Cryptorchidism--A Nationwide Cohort Study
Am. J. Epidemiol., June 15, 2008; 167(12): 1453 - 1457.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
N A Abdullah, M S Pearce, L Parker, J R Wilkinson, B Jaffray, and R J Q McNally
Birth prevalence of cryptorchidism and hypospadias in northern England, 1993-2000
Arch. Dis. Child., July 1, 2007; 92(7): 576 - 579.
[Abstract] [Full Text] [PDF]

Home page
 Int J EpidemiolHome page
K. A McGlynn, B. I Graubard, M. A Klebanoff, and M. P Longnecker
Risk factors for cryptorchism among populations at differing risks of testicular cancer
Int. J. Epidemiol., June 1, 2006; 35(3): 787 - 795.
[Abstract] [Full Text] [PDF]

Home page
 Br Med BullHome page
M. Joffe
Infertility and environmental pollutants
Br. Med. Bull., December 1, 2003; 68(1): 47 - 70.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
P. F. Thonneau, P. Candia, and R. Mieusset
Cryptorchidism: Incidence, Risk Factors, and Potential Role of Environment; An Update
J Androl, March 1, 2003; 24(2): 155 - 162.
[Full Text] [PDF]

Home page
 Int J EpidemiolHome page
S. Liu, R. Semenciw, C. Waters, S. W. Wen, L. S Mery, and Y. Mao
Clues to the aetiological heterogeneity of testicular seminomas and non-seminomas: time trends and age-period-cohort effects
Int. J. Epidemiol., October 1, 2000; 29(5): 826 - 831.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol Ind HealthHome page
F. Olea-Serrano, P. Lardelli-Claret, A. Rivas, A. Barba-Navarro, and N. Olea
Inadvertent exposure to xenoestrogens in children
Toxicology and Industrial Health, February 1, 1999; 15(1-2): 152 - 159.
[Abstract] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.