Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by BRINTON, L. A.
Right arrow Articles by FRAUMENI, J. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by BRINTON, L. A.
Right arrow Articles by FRAUMENI, J. F., Jr
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1982 Oxford University Press

research-article

Oral Contraceptives and Breast Cancer

LOUISE A. BRINTON*, ROBERT HOOVER*, MOYSES SZKLO{dagger} and JOSEPH F. FRAUMENI, Jr*

* Environmental Epidemiology Branch, National Cancer Institute Landow Building 3CO6, Bethesda, MD 20205, USA.
{dagger}Department of Epidemiology, The Johns Hopkins University Baltimore, MD 21205, USA.

Brinton L A (Enviromental Epidemiology Brach, National Cancer Institute, Landow Building 3CO6, Bethesda, MD 20205, USA), Hoover R, Szklo M and Fraumeni J F Jr. Oral contraceptives and breast cancer. International Journal of Epidemiology 1982, 11:316–322.

A case-control interview study, conducted among participants in the Breast Cancer Detection Demonstration Project and involving 963 breast cancer cases and 858 controls, allowed evaluation of the risk of breast cancer associated with use of oral contraceptives. Overall, there was no association between use and risk of disease (RR=1.1). In addition, there was no indication of increasing risk with years of use or years since initial use, despite slight excess risks observed among users of high-dose preparations. Premenopausal women who used the pill after the age of 40 demonstrated approximately a 50% increased risk, possibly as a result of artificial prolongation of a premenopausal rate of disease incidence. Non-significant excess risks associated with pill use were also seen among premenopausal women who reported a family history of breast cancer in a sister (RR = 3.6) or previous biopsies for benign breast disease (RR = 3.2). The latter excess was limited to women whose use of the pill preceded a first biopsy, suggesting that the types of lesions requiring biopsy among current long-term pill users may be those that predispose to breast cancer.

Received 1 February 1982


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 JAMAHome page
J. J. Schlesselman, B. V. Stadel, P. Murray, and S. Lai
Breast Cancer in Relation to Early Use of Oral Contraceptives: No Evidence of a Latent Effect
JAMA, March 25, 1988; 259(12): 1828 - 1833.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.