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© 1982 Oxford University Press

research-article

Oestrogens and Obesity as Risk Factors for Endometrial Cancer in Italy

CARLO LA VECCHIA*, SILVIA FRANCESCHI*, GIUSEPPE GALLUS{dagger}, ADRIANO DECARLA{dagger}, ELENA COLOMBO{ddagger}, COSTANTINO MANGIONI{ddagger} and GIANNI TOGNONI*

*Istituto di Ricerche Farmacologiche ‘Mario Negri’, Via Eritrea 62–20157 MILANO (Italy).
*Istituto di Ricerche Farmacologiche ‘Mario Negri’, Via Eritrea 62–20157 MILANO (Italy).
{dagger}Istituto di Biometria e Statistica Medica, University of Milan Via Venezian, 1 MILANO (Italy).
{dagger}Istituto di Biometria e Statistica Medica, University of Milan Via Venezian, 1 MILANO (Italy).
{ddagger}I Clinica Ostetrica Ginecologica, University of Milan, Via Commenda 12 MILANO (Italy).
{ddagger}I Clinica Ostetrica Ginecologica, University of Milan, Via Commenda 12 MILANO (Italy).
*Istituto di Ricerche Farmacologiche ‘Mario Negri’, Via Eritrea 62–20157 MILANO (Italy).

La Vecchia C (Istituto di Ricerche Farmacologiche ‘Mario Negri’, Via Eritrea, 62–20157 Milano, Italy) et al. Oestrogens and obesity as risk factors for endometrial cancer in Italy. International Journal of Epidemiology 1982, 11: 120–126.

Inn a case-control study evaluate risk factors for endometrial cancer, obesity., history of various disease, reproductive and menstrual characteristics, marital status, education, and lifetime use of female hormones were examined in 173 histologically proven endometrial cancers and 347 controls. non-contraceptive oestrogen use, late menopause. low parity and history of uterine fibromomas were associated with an increased risk of endometrial cancer. The relative risks of obesity and oestrogen use seem to fit well for an additive model.Histological differntialion was positively correlated both to oestrogen use and to level of iverweight, supporting the hyposthesis of a specific role of ioestrogens in endometrial cancer.

Revised 3 October 1981


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