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© 1972 Oxford University Press

research-article

Evaluation of Preventive Measures in High Risk Subjects

D. SCHWARTZ1

1 Directeur de I'Unité de Recherches Statistiques de l'Institut National de la Santé et de la Recherche Medicale, 94-Villejuif (France).

Schwartz, D. (Unit6 de Recherches Statistiques de L'lnstitut National de la Santd et de la Recherche Medicale, 94-Villejuif, France). Evaluation of preventive measures in high risk subjects. Int. J. Epid. 1972,1: 51–53.

The evaluation of the effects of a treatment for a chronic degenerative disease is conceived as a three stage procedure:

1. Evaluation of the risk.

2. Identification of the high risk subjects.

3. Validation of the effects of preventive measures in the high risk subjects by controlled clinical trial.

These points are discussed, and in particular the third, for the controlled clinical trial in this case differs in many respects from the classical trial carried out in therapy.

The two possible approaches to validation of preventive measures, ‘explanatory’ and ‘pragmatic’, are considered with respect to how each affects the choice of subjects, of treatments and criteris of assessment.


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