© 1972 Oxford University Press
research-article |
Controlled Field Trials of Oral Killed Typhoid Vaccines in India
1 Professor of Epidemiology, National Institute of Health Administration and Education, E-16, Greater Kailash, New Delhi 48, India
2 Lecturer, Dept. of Microbiology, Maulana Azad Medical College, New Delhi
3 Lecturer, Dept. of Microbiology, Maulana Azad Medical College, New Delhi
4 Assistant Research Officer, Indian Council of Medical Research, New Delhi
5 Assistant Director, Dept. of Statistics, National Institute of Communicable Disease, New Delhi
6 Professor of Microbiology, Maulana Azad Medical College, New Delhi. (Trial No. 1)
7 Professor of Microbiology, Maulana Azad Medical College, New Delhi. (Trial No. 2)
Requests for reprints may be addressed to Dr.C. S. Chuttani
Chuttani, C. S. (National Institute of Health Administration and Education, E-16, Greater Kailash, New Delhi 48, India), Prakash, K., Vergese, A., Sharma, U., Singha, P., Ghosh Ray, B., and Agarwal, D. S. Controlled field trials of oral killed typhoid vaccines in India. Int. J. Epid. 1972,1: 39–43.
The results of two controlled field trials of oral killed typhoid vaccines, carried out in Delhi, India, are discussed. In the first trial, conducted in 1968–69, a vaceine containing 100 x 109 killed bacteria was given in tablet form to 6, 060 children, and a placebo given to 6, 248 children. The difference in attack rate (9–6 per thousand in the control groups and 7–3 per thousand in the vaccinated group) was not significant.
In the second trial, the dosage of the vaccine was increased (300 x 109 bacteria per tablet). The vaccinated group contained 6, 136 children, and the control group, 6, 428. The difference in attack rate between the two groups (7.6 per thousand in the control and 8.4 per thousand in the vaccinated group) was again not significant. Both the vaccines used in these trials were found to be ineffective against typhoid. The advantages of carrying out such trials in areas of high morbidity are discussed.